One in four mortgage intermediaries say they have seen business volumes fall following the introduction of the Mortgage Market Review (MMR).
The majority said the volumes have fallen by up to 30%.
The new survey by Paragon Mortgages also showed that 43% of brokers had seen no change in business since MMR was launched on 25 April last year, almost exactly one year ago
Paragon's Financial Advisor Confidence Tracking survey (FACT) also found that 15% of intermediaries did not know what the long-term impacts of the new regulations would be.
When asked which of their customers is now most difficult to find a mortgage for, 75% said the self-employed.
That was followed by retired customers and customers with complex incomes, both named by half of intermediaries surveyed.
John Heron, director of Paragon Mortgages, said: "There is still some uncertainty in the market about the long-term impact the MMR changes will have on business volumes.
"This isn't unexpected, as with any significant change in regulation there will always be a period of adjustment, but it is important the industry monitors this carefully."
Heron said the research also showed what lenders could be doing better. "We need to recognise that there is no such thing as the average mortgage customer anymore, people have a greater variety of circumstances and we need to be more innovative in order to meet increasingly varied demand."
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